Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …

▪ Abstract Microtubules are polymers that are essential for, among other functions, cell
transport and cell division in all eukaryotes. The regulation of the microtubule system …

Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol
has dramatically increased. Although treatment with Taxol has led to improvement in the …

Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …

Microtubules are important cellular targets for anticancer therapy because of their key role in
mitosis. Microtubule inhibitors (MTI) such as taxanes, vinca alkaloids, and epothilones …

Paclitaxel, a tetracyclic diterpenoid compounds, was firstly isolated from the bark of the
Pacific yew trees. Currently, as a low toxicity, high efficiency, and broad-spectrum natural …

Microtubules are intrinsically dynamic polymers, and their dynamics play a crucial role in
mitotic spindle assembly, the mitotic checkpoint, and chromosome movement. We …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …