Context.—Controversies and uncertainty persist in prostate cancer grading. Objective.—To
update grading recommendations. Data Sources.—Critical review of the literature along with …

Five years after the last prostatic carcinoma grading consensus conference of the
International Society of Urological Pathology (ISUP), accrual of new data and modification of …

Early identification and management of prostate cancer completely changed with the
discovery of prostate-specific antigen. However, improved detection has also led to …

Purpose Following a prostate cancer diagnosis, patients are faced with a multitude of care
options, the advisability of which is influenced by patient factors and by cancer severity or …

Background Multiparametric magnetic resonance imaging (mpMRI) has an established role
for the diagnosis of clinically significant prostate cancer (sPCa). The PRIMARY trial …

Background Although numerous studies have shown that perineural invasion (PNI) is linked
to prostate cancer (PCa) risk, the results have been inconsistent. This study aimed to explore …

Gleason grading of prostate cancer has gained worldwide acceptance since its introduction
50 years ago. This system has fulfilled the role of a powerful prognostic indicator for many …

Purpose: To our knowledge the ideal methodology of quantifying secondary Gleason pattern
4 in men with Grade Group 2/Gleason score 3+ 4= 7 on biopsy remains unknown. We …

The use of PSA screening has led to downstaging and downgrading of prostate cancer at
diagnosis, increasing detection of indolent disease. Active surveillance aims to reduce over …

Despite the innovations made to enhance smarter screening and conservative management
for low-grade prostate cancer, overdiagnosis, and overtreatment remains a major health …