The innate immune system responds to inflammation, infection and injury by recruiting
neutrophils and other leukocytes. These cells are able to leave the intravascular …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Leukocyte trafficking from the blood stream to tissues is essential for continuous surveillance
of foreign antigens. This dynamic process, designated as the leukocyte adhesion cascade …

A monoclonal antibody (904) that binds to a leukocyte cell adhesion-promoting
glycoprotein,(Mo1; CD11b/CD18) was administered (1 mg/kg, iv.) to open chest …

Cell adhesion molecules are glycoproteins expressed on the cell surface and play an
important role in inflammatory as well as neoplastic diseases. There are four main groups …

Publisher Summary This chapter focuses on the molecular biology of the leukocyte integrins,
LFA-1, Mac-1, and p150, 95, and on their role in mediating inflammation. Three recent …

Leukocyte adhesion deficiency disease is characterized by a mutation in the gene encoding
the beta-subunit shared by three adhesive heterodimers, LFA-1, Mac-1 (CR3) and p150, 95 …

Leukocytosis (34,600 wbc/μl of blood) was detected in an apparently healthy 7-day-old
Holstein heifer. Analysis of blood samples obtained over the next 41 days revealed chronic …

Publisher Summary This chapter discusses the key adhesion molecules involved in
leukocyte trafficking to sites of inflammation, focuses on mechanisms to regulate adhesion …

Cardiac myocytes were isolated from adult dogs and incubated with isolated canine
neutrophils (PMN). Intercellular adhesion was low and unchanged by stimulation of the PMN …