Drug resistance remains a major hurdle to successful cancer treatment, being accountable
for approximately 90% of cancer-related deaths. In the past years, increasing attention has …

Following their discovery at the end of the 20th century, extracellular vesicles (EVs) ranging
from 50-1,000 nm have proven to be paramount in the progression of many cancers …

Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy
failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding …

Background/Objectives: A key role of extracellular vesicles (EVs) is mediating both cell–cell
and cell–stroma communication in pathological/physiological conditions. EVs from resistant …

Despite their small size, the membrane-bound particles named extracellular vesicles (EVs)
seem to play an enormous role in the pathogenesis of acute leukemia. From oncogenic …

Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents.
Despite aggressive treatment regimens, the outcome is unsatisfactory, and multidrug …

Extracellular vehicles (EVs) are gaining increasing recognition as central contributors to the
intricate landscape of the tumor microenvironment (TME). This manuscript provides an …

Background The progression of leukemia is substantially associated with the interactions of
leukemic cells with surrounding cells within the bone marrow microenvironment (BMM), and …

Clinical translation of autophagy modulators is tied to thoroughly acquainted with the precise
state of this process and its regulators in a particular cancer. LC3Av1 is a marker of …

Despite significant advancements in the treatment of cancer, therapeutic resistance remains
a major hurdle for the achievement of full cures. Besides being typically driven by …