Estetrol: from preclinical to clinical pharmacology and advances in the understanding of the molecular mechanism of action

C Gérard, JM Foidart - Drugs in R&D, 2023 - Springer
Estetrol (E4) is the most recently described natural estrogen. It is produced by the human
fetal liver during pregnancy and its physiological function remains unclear. E4 is the …

Drospirenone and estetrol: evaluation of a newly approved novel oral contraceptive

AL Nelson - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
Introduction Estetrol (E4) is a native estrogen produced only by the fetal liver during
pregnancy. E4 is the first new estrogen to be used in hormonal contraception since the …

The efficacy, safety, and tolerability of an estrogen-free oral contraceptive drospirenone 4 mg (24/4-day regimen) in obese users

MD Creinin, A Angulo, E Colli, DF Archer - Contraception, 2023 - Elsevier
Objectives This study aimed to compare contraceptive efficacy and safety of drospirenone 4
mg in a 24/4-day regimen in nonobese and obese users and describe pharmacokinetics …

[HTML][HTML] The benefits of estetrol addition to drospirenone for contraception

JM Foidart, K Gemzell-Danielsson, A Kubba… - AJOG global reports, 2023 - Elsevier
Ethinylestradiol and drospirenone combined oral contraceptive formulations have been
marketed for> 20 years. Drospirenone has antimineralocorticoid and anti-androgenic effects …

[HTML][HTML] The clinical relevance of having more than one estrogen in combined hormonal contraception to address the needs of women

C Frisendahl, HK Kallner… - Best Practice & Research …, 2024 - Elsevier
This chapter examines the potential of natural estrogens, particularly estradiol and estetrol,
in combined hormonal contraceptive pills as alternatives to the widely used synthetic ethinyl …

Combined oral contraceptive with estetrol plus drospirenone: from pharmacokinetics to clinical applications

C Battipaglia, L Feliciello, AD Genazzani… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Drospirenone/estetrol (DRSP/E4) is a combined oral contraceptive
(COC) recently approved in several countries. It is composed of 15 mg of E4, a natural …

Combined oral contraceptive adherence and pregnancy rates

MD Creinin, JT Jensen, MJ Chen, A Black… - Obstetrics & …, 2023 - journals.lww.com
OBJECTIVE: To assess the relationship of adherence and pregnancy in participants using
an estetrol and drospirenone combined oral contraceptive. METHODS: We performed a …

El papel del estetrol en la anticoncepción: una revisión integral

M Sánchez-Prieto, C Llaneza-Suárez, A Beta… - Revista chilena de …, 2024 - SciELO Chile
Esta revisión narrativa explora el papel potencial del estetrol (E4), un esteroide estrogénico
natural, en la anticoncepción, analizando sus propiedades farmacológicas, su efectividad y …

Comparative efficacy of combined oral contraceptives and the levonorgestrel 52 mg IUD

MD Creinin, JA Brown, HA Rankin, S Yazdani - European Journal of …, 2024 - Elsevier
Comparative efficacy of combined oral contraceptives and the levonorgestrel 52 mg IUD -
ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books Help …

Эстетрол: натуральный эстроген с селективной тканевой активностью в составе нового комбинированного орального контрацептива

РИ Габидуллина - Вопросы гинекологии, акушерства и перинатологии, 2022 - elibrary.ru
В обзоре представлены современные данные о свойствах эстетрола, а также нового
комбинированного орального контрацептива (КОК), содержащего эстетрол и …