Macrophages, important cells of innate immunity, are known for their phagocytic activity,
capability for antigen presentation, and flexible phenotypes. Macrophages are found in all …

Gene delivery/expression vectors have been used as fundamental technologies in gene
therapy since the 1980s. These technologies are also being applied in regenerative …

The ectopic expression of transcription factors can reprogram differentiated tissue cells into
induced pluripotent stem cells. However, this is a slow and inefficient process, depending on …

Human (h) induced pluripotent stem cells (iPSCs) are a potentially abundant source of blood
cells, but how best to select iPSC clones suitable for this purpose from among the many …

The transient delivery of gene products (RNA or proteins) is not a biotechnological invention
but rather an evolutionarily conserved process underlying and regulating a variety of …

Use of RNA is an increasingly popular method to transiently deliver genetic information for
cell manipulation in basic research and clinical therapy. In these settings, viral and nonviral …

The incorporation of nanotechnology in regenerative medicine is at the nexus of
fundamental innovations and early‐stage breakthroughs, enabling exciting biomedical …

The advent of RNA-guided endonuclease (RGEN)-mediated gene editing, specifically via
CRISPR/Cas9, has spurred intensive efforts to improve the efficiency of both RGEN delivery …

The detailed mechanism of reprogramming somatic cells into induced pluripotent stem cells
(iPSCs) remains largely unknown. Partially reprogrammed iPSCs are informative and useful …

Pluripotent stem cells (PSCs) have various degrees of pluripotency, which necessitates
selection of PSCs with high pluripotency before their application to regenerative medicine …