DNA repair pathway choices in CRISPR-Cas9-mediated genome editing
Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
M Ito, Y Fujita, A Shinohara - DNA repair, 2024 - Elsevier
RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …
RAD51 bypasses the CMG helicase to promote replication fork reversal
Replication fork reversal safeguards genome integrity as a replication stress response. DNA
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …
BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
Tumor suppressor BRCA2 functions in homology-directed repair (HDR), the protection of
stalled replication forks, and the suppression of replicative gaps, but their relative …
stalled replication forks, and the suppression of replicative gaps, but their relative …
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA
Templated DNA repair that occurs during homologous recombination and replication stress
relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs …
relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs …
FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading
A Zainu, P Dupaigne, S Bouchouika, J Cau… - Nature …, 2024 - nature.com
During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
K Tsukada, SE Jones, J Bannister, MA Durin, I Vendrell… - Molecular Cell, 2024 - cell.com
The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1, and
RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA …
RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA …
RNase H1 facilitates recombinase recruitment by degrading DNA–RNA hybrids during meiosis
C Liu, L Wang, Y Li, M Guo, J Hu, T Wang… - Nucleic Acids …, 2023 - academic.oup.com
DNA–RNA hybrids play various roles in many physiological progresses, but how this
chromatin structure is dynamically regulated during spermatogenesis remains largely …
chromatin structure is dynamically regulated during spermatogenesis remains largely …
Multi-scale characterisation of homologous recombination deficiency in breast cancer
Background Homologous recombination is a robust, broadly error-free mechanism of double-
strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying …
strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying …
SMAD4 limits PARP1 dependent DNA repair to render pancreatic Cancer cells sensitive to Radiotherapy
Y Wang, T Yu, Z Zhao, X Li, Y Song, Y He, Y Zhou… - Cell Death & …, 2024 - nature.com
Dysregulation of SMAD4 (ie somatic mutation) is strongly associated with poor pancreatic
ductal adenocarcinoma (PDAC) prognosis, yet the molecular mechanisms remain …
ductal adenocarcinoma (PDAC) prognosis, yet the molecular mechanisms remain …