Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …

Neurons require large amounts of energy, but whether they can perform glycolysis or require
glycolysis to maintain energy remains unclear. Using metabolomics, we show that human …

The SIRT6 deacetylase has been implicated in DNA repair, telomere maintenance, glucose
and lipid metabolism and, importantly, it has critical roles in the brain ranging from its …

Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging
phenotypes and age-related diseases. Here, we report that impaired mitochondrial function …

Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate
(ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the …

Neural tissue has high metabolic requirements. Following spinal cord injury (SCI), the
damaged tissue suffers from a severe metabolic impairment, which aggravates axonal …

Primary mitochondrial diseases (PMD) refer to a group of severe, often inherited genetic
conditions due to mutations in the mitochondrial genome or in the nuclear genes encoding …

Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …

Inflammation in the central nervous system can impair the function of neuronal mitochondria
and contributes to axon degeneration in the common neuroinflammatory disease multiple …