Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of
cell fate determination and differentiation in stem and progenitor cells during normal …

The Trk family of receptors play a wide variety of roles in physiological and disease
processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in …

The focus of this review is to critically examine and review the literature on the role of brain-
derived neurotrophic factor (BDNF) and its primary receptor, tropomyosin-related kinase B …

Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for
proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains …

Chromatin remodeling complexes play crucial roles in transcription and are implicated in
processes including cell proliferation, differentiation and embryonic patterning. Brg1 is the …

Small-cell lung cancer and other aggressive neuroendocrine cancers are often associated
with early dissemination and frequent metastases. We demonstrate that neurogenic …

NeuroD (otherwise known as BETA2) is a basic helixloop-helix (bHLH) transcription factor
that is capable of converting embryonic epidermal cells into fully differentiated neurons in …

Mesenchymal stem cells (MSCs) have been shown to ameliorate a variety of neurological
dysfunctions. This effect is believed to be mediated by their paracrine functions, since these …

Abstract 1α, 25-Dihydroxyvitamin D 3 (1α, 25 (OH) 2 D 3) has antitumor activity in addition to
its classical action on calcium metabolism and bone tissue biology. It is thought to regulate …