[HTML][HTML] The progression of geographic atrophy secondary to age-related macular degeneration

M Fleckenstein, P Mitchell, KB Freund, SV Sadda… - Ophthalmology, 2018 - Elsevier
Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD)
that leads to progressive and irreversible loss of visual function. Geographic atrophy is …

Complement inhibition for geographic atrophy: review of salient functional outcomes and perspective

RF Spaide, DG Vavvas - Retina, 2023 - journals.lww.com
Purpose: To evaluate available rationale and outcomes of randomized trial results for
complement inhibition for geographic atrophy. Methods: Data from recently completed …

Progression of geographic atrophy in age-related macular degeneration: AREDS2 report number 16

TD Keenan, E Agrón, A Domalpally, TE Clemons… - Ophthalmology, 2018 - Elsevier
Purpose To analyze the prevalence, incidence, and clinical characteristics of eyes with
geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and …

Incidence and growth of geographic atrophy during 5 years of comparison of age-related macular degeneration treatments trials

JE Grunwald, M Pistilli, E Daniel, GS Ying, W Pan… - Ophthalmology, 2017 - Elsevier
Purpose To estimate the incidence, size, and growth rate of geographic atrophy (GA) during
5 years of follow-up among participants in the Comparison of Age-Related Macular …

Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials

JE Grunwald, M Pistilli, G Ying, MG Maguire, E Daniel… - Ophthalmology, 2015 - Elsevier
Purpose To evaluate the growth of geographic atrophy (GA) during anti–vascular
endothelial growth factor (VEGF) therapy. Design Cohort within a clinical trial. Participants …

[HTML][HTML] Emixustat hydrochloride for geographic atrophy secondary to age-related macular degeneration: a randomized clinical trial

PJ Rosenfeld, PU Dugel, FG Holz, JS Heier… - Ophthalmology, 2018 - Elsevier
Purpose To determine whether emixustat hydrochloride (emixustat) reduces the rate of
enlargement of geographic atrophy (GA) compared with placebo in subjects with age …

Geographic atrophy in patients with advanced dry age-related macular degeneration: current challenges and future prospects

RP Danis, JA Lavine, A Domalpally - Clinical Ophthalmology, 2015 - Taylor & Francis
Geographic atrophy (GA) of the retinal pigment epithelium (RPE) is a devastating
complication of age-related macular degeneration (AMD). GA may be classified as drusen …

Investigational drugs inhibiting complement for the treatment of geographic atrophy

L Ferro Desideri, D Artemiev, E Bernardi… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Geographic atrophy (GA) is a progressive form of age-related macular
degeneration (AMD) that leads to severe visual impairment and central vision loss …

Enlargement of geographic atrophy from first diagnosis to end of life

JM Colijn, B Liefers, N Joachim, T Verzijden… - JAMA …, 2021 - jamanetwork.com
Importance Treatments for geographic atrophy (GA), a late stage of age-related macular
degeneration (AMD), are currently under development. Understanding the natural course is …

Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration

F Grassmann, M Fleckenstein, EY Chew, T Strunz… - PLoS …, 2015 - journals.plos.org
Worldwide, age-related macular degeneration (AMD) is a serious threat to vision loss in
individuals over 50 years of age with a pooled prevalence of approximately 9%. For 2020 …