The monoamine hypothesis has been accepted as the most common hypothesis of major
depressive disorder (MDD) for a long period because of its simplicity and understandability …

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

Leading a mentally stimulating life may build up a reserve of neural and mental resources
that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density …

The gap between symptoms and pathology in Alzheimer's disease has been explained by
the hypothetical construct of “cognitive reserve”—a set of variables including education …

The original definition of atypical antipsychotic drugs (APD) was drugs that are effective
against positive symptoms in schizophrenia with no or little extrapyramidal symptoms (EPS) …

Enriched sensorimotor environments enable rodents to compensate for a wide range of
neurological challenges, including those induced in animal models of autism. Given the …

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …

Abstract Alzheimer's disease (AD), as a neurodegenerative process caused by widespread
senile plaques and neurofibrillary tangles, is faced with an increasingly higher incidence as …

It is now well established that all clinically available antidepressants share a common
aptitude: they increase the production of adult-generated neurons in the dentate gyrus of the …