[HTML][HTML] Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus
ES Green, PC Arck - Seminars in immunopathology, 2020 - Springer
Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …
[HTML][HTML] The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes
Background Intra-amniotic infection is present in 10% of patients with an episode of preterm
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
Spontaneous preterm birth: advances toward the discovery of genetic predisposition
Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …
[PDF][PDF] Regulatory T cells play a role in a subset of idiopathic preterm labor/birth and adverse neonatal outcomes
Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy;
however, their role later in gestation is poorly understood. Herein, we report that functional …
however, their role later in gestation is poorly understood. Herein, we report that functional …
Inflammasomes: their role in normal and complicated pregnancies
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …
responses, including those that take place during pregnancy. Inflammasomes and their …
Effector and activated T cells induce preterm labor and birth that is prevented by treatment with progesterone
M Arenas-Hernandez, R Romero, Y Xu… - The Journal of …, 2019 - journals.aai.org
Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity
and mortality worldwide. Most research has focused on establishing a causal link between …
and mortality worldwide. Most research has focused on establishing a causal link between …
[HTML][HTML] Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified …
Background The major challenge for obstetrics is the prediction and prevention of the great
obstetrical syndromes. We propose that defining obstetrical diseases by the combination of …
obstetrical syndromes. We propose that defining obstetrical diseases by the combination of …
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B
Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A
substantial number of spontaneous preterm births occur in the context of sterile intra …
substantial number of spontaneous preterm births occur in the context of sterile intra …
[HTML][HTML] Fetal and maternal NLRP3 signaling is required for preterm labor and birth
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …