The molecular basis for cellular function of intrinsically disordered protein regions
AS Holehouse, BB Kragelund - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Advances in targeting 'undruggable'transcription factors with small molecules
MJ Henley, AN Koehler - Nature Reviews Drug Discovery, 2021 - nature.com
Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
Tranception: protein fitness prediction with autoregressive transformers and inference-time retrieval
The ability to accurately model the fitness landscape of protein sequences is critical to a
wide range of applications, from quantifying the effects of human variants on disease …
wide range of applications, from quantifying the effects of human variants on disease …
Proteingym: Large-scale benchmarks for protein fitness prediction and design
Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins to address our most pressing …
understanding genetic disease to designing novel proteins to address our most pressing …
[HTML][HTML] Transcription factors activate genes through the phase-separation capacity of their activation domains
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
Large-scale mapping and mutagenesis of human transcriptional effector domains
Human gene expression is regulated by more than 2,000 transcription factors and chromatin
regulators,. Effector domains within these proteins can activate or repress transcription …
regulators,. Effector domains within these proteins can activate or repress transcription …
Imaging dynamic and selective low-complexity domain interactions that control gene transcription
INTRODUCTION DNA binding transcription factors (TFs) are quintessential regulators of
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure
Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …
proteomes in which they play a wide variety of essential roles. A critical first step in …
Transcription activation is enhanced by multivalent interactions independent of phase separation
J Trojanowski, L Frank, A Rademacher, N Mücke… - Molecular cell, 2022 - cell.com
Transcription factors (TFs) consist of a DNA-binding domain and an activation domain (AD)
that are frequently considered to be independent and exchangeable modules. However …
that are frequently considered to be independent and exchangeable modules. However …
[HTML][HTML] Directed mutational scanning reveals a balance between acidic and hydrophobic residues in strong human activation domains
MV Staller, E Ramirez, SR Kotha, AS Holehouse… - Cell systems, 2022 - cell.com
Acidic activation domains are intrinsically disordered regions of the transcription factors that
bind coactivators. The intrinsic disorder and low evolutionary conservation of activation …
bind coactivators. The intrinsic disorder and low evolutionary conservation of activation …