Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of
atherosclerosis and a significant risk factor for the development of cardiovascular events. In …

G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …

The series of reactive biological events that we identify as inflammation has been
investigated in recent years and unveiled as an important mechanism for regeneration. The …

Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact
molecular processes underlying this disorder are not fully known. This study includes a …

Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart
disease. However, how RAS activation causes cardiac lesions remains elusive. Here we …

Doxorubicin (DOXO) is commonly used to treat a wide range of malignant tumors, but its
clinical use is limited by acute and chronic cardiotoxicity. The precise mechanism underlying …

Both cardiovascular disease and aging are associated with changes in the sympathetic
nervous system. Indeed, mounting evidence indicates that adrenergic receptors are …

Cardiovascular diseases (CVD) have been recognized as the leading cause of mortality
worldwide, accounting for 31% of global mortality. Among the risk factors of CVD …

Heart failure and cardiovascular disorders represent the leading cause of death in diabetic
patients. Here we present a systematic review of the main mechanisms underlying the …

Inflammation has emerged as an important contributor to heart failure (HF) development and
progression. Current research data highlight the diversity of immune cells, proteins, and …