The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

The use of genetically manipulated mouse models, gene and protein discovery and the
cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal …

Sex steroids are chief regulators of gender differences in the skeleton, and male gender is
one of the strongest protective factors against osteoporotic fractures. This advantage in bone …

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal
antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) …

Reproductive hormones play a crucial role in the growth and maintenance of the
mammalian skeleton. Indeed, the biological significance for this hormonal regulation of …

Bone is a dynamic organ constantly remodeled to support calcium homeostasis and
structural needs. The osteoclast is the cell responsible for removing both the organic and …

Male osteoporosis is a still largely underdiagnosed pathological condition. As a
consequence, bone fragility in men remains undertreated mainly due to the low screening …

The past decade has seen significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent …

Inflammation is an immediate response that plays a critical role in healing after fracture or
injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in …

The inflammation of aging hypothesis purports that aging is the accumulation of damage,
which results, in part, from chronic activation of inflammation process. We tested this …