Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …

Macrophages infected with Gram-negative bacteria expressing Type III secretion system
(T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent …

Nigericin, an ionophore derived from Streptomyces hygroscopicus, is arguably the most
commonly used tool compound to study the NLRP3 inflammasome. Recent findings …

Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …

Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

Summary Elevated interleukin (IL)-1β levels, NLRP3 inflammasome activity, and systemic
inflammation are hallmarks of chronic metabolic inflammatory syndromes, but the …