Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics

MS Islam, A Ciavattini, F Petraglia… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

[HTML][HTML] Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity

MG Munro - Fertility and sterility, 2019 - Elsevier
Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered
abnormalities frequently found in both fertile women and those with infertility. The clinician is …

Uterine fibroid management: from the present to the future

J Donnez, MM Dolmans - Human reproduction update, 2016 - academic.oup.com
Uterine fibroids (also known as leiomyomas or myomas) are the most common form of
benign uterine tumors. Clinical presentations include abnormal bleeding, pelvic masses …

[HTML][HTML] Understanding the impact of uterine fibroids on human endometrium function

A Navarro, MV Bariani, Q Yang… - Frontiers in cell and …, 2021 - frontiersin.org
Uterine fibroids (leiomyomas) are the most common benign gynecological tumors in women
of reproductive age worldwide. They cause heavy menstrual bleeding, usually leading to …

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation

T Iizuka, P Yin, A Zuberi, S Kujawa… - Proceedings of the …, 2022 - National Acad Sciences
Uterine leiomyoma is the most common tumor in women and causes severe morbidity in 15
to 30% of reproductive-age women. Epidemiological studies consistently indicate a …

Regulation and functions of integrin α2 in cell adhesion and disease

V Adorno-Cruz, H Liu - Genes & diseases, 2019 - Elsevier
Integrins are cell adhesion molecules that are composed of an alpha (α) subunit and a beta
(β) subunit with affinity for different extracellular membrane components. The integrin family …

Pathogenomics of uterine fibroids development

VS Baranov, NS Osinovskaya… - International journal of …, 2019 - mdpi.com
We review recent studies dealing with the molecular genetics and basic results of omics
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …

Uterine stem cells: from basic research to advanced cell therapies

X Santamaria, A Mas, I Cervelló… - Human Reproduction …, 2018 - academic.oup.com
BACKGROUND Stem cell research in the endometrium and myometrium from animal
models and humans has led to the identification of endometrial/myometrial stem cells and …

Mediator kinase module and human tumorigenesis

AD Clark, M Oldenbroek, TG Boyer - Critical reviews in …, 2015 - Taylor & Francis
Mediator is a conserved multi-subunit signal processor through which regulatory
informatiosn conveyed by gene-specific transcription factors is transduced to RNA …

Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics

M Ali, M Ciebiera, S Vafaei, S Alkhrait, HY Chen… - Cells, 2023 - mdpi.com
Uterine fibroids (UFs) are the most important benign neoplastic threat to women's health
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …