[HTML][HTML] Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review

SH Lee, JT Sohn - Korean Journal of Anesthesiology, 2023 - synapse.koreamed.org
Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST).
LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local …

Lipid emulsion to treat acute poisonings: mechanisms of action, indications, and controversies

K Jaffal, L Chevillard, B Mégarbane - Pharmaceutics, 2023 - mdpi.com
Biodetoxification using intravenous lipid emulsion (ILE) in acute poisoning is of growing
interest. As well as for local anesthetics, ILE is currently used to reverse toxicity caused by a …

Confusion about infusion: rational volume limits for intravenous lipid emulsion during treatment of oral overdoses

MR Fettiplace, BS Akpa, I Rubinstein… - Annals of emergency …, 2015 - annemergmed.com
After the initial report of treatment of bupropion and lamotrigine overdose by intravenous
lipid emulsion, 1 additional case reports have asserted the usefulness of lipid emulsion for …

Lipid emulsion therapy during management of the critically-ill poisoned patient: a prospective cohort study

M Levine, J Brent, T Wiegand, B Maguire… - Clinical …, 2023 - Taylor & Francis
Background Despite conflicting data, intravenous lipid emulsion has emerged as a potential
antidote. The “lipid sink” theory suggests that following intravenous administration of lipid …

Lipid emulsion in local anesthetic toxicity

M Harvey, G Cave - Current Opinion in Anesthesiology, 2017 - journals.lww.com
Lipid emulsion in local anesthetic toxicity : Current Opinion in Anesthesiology Lipid emulsion
in local anesthetic toxicity : Current Opinion in Anesthesiology Log in or Register Subscribe to …

Local anesthetic systemic toxicity

L Warren, A Pak - UpToDate, Post TW, editorAccessed December, 2019 - uptodate.com
Local anesthetics (LAs) are administered in practice by many clinicians, including
anesthesia clinicians, surgeons, emergency department providers, dentists, and others …

Literature review of the evidence regarding intravenous lipid administration in drug-induced cardiotoxicity

M Paneta, WS Waring - Expert Review of Clinical Pharmacology, 2019 - Taylor & Francis
Introduction: Intravenous lipid emulsion (ILE) administration is capable of reversing the
acute cardiac and neurological toxicity caused by local anesthetic agents. In recent years …

High-dose intravenous lipid emulsion affecting successful initiation of continuous venovenous hemofiltration and extracorporeal membrane oxygenation

JH Sin, A Tom, A Toyoda, N Roy, BD Hayes - Clinical Toxicology, 2018 - Taylor & Francis
An unidentified middle-aged female suffered a pulseless electrical activity (PEA) arrest after
presumably ingesting unknown amounts of diltiazem extended-release, digoxin, and …

[PDF][PDF] Current evidence is not in support of lipid rescue therapy in local anaesthetic systemic toxicity

PH Rosenberg - Acta Anaesthesiologica Scandinavica, 2016 - perioptalk.org
It is now 10 years since the first case reports of the use of intravenous lipid emulsion (ILE) as
treatment for local anaesthetic systemic toxicity (LAST). 1, 2 In spite of very scarce data on …

Lipid resuscitation in acute poisoning: after a decade of publications, what have we really learned?

LCG Hoegberg, S Gosselin - Current Opinion in Anesthesiology, 2017 - journals.lww.com
ILE can be used to resuscitate local anesthetics especially bupivacaine. The impact of ILE
on oral overdoses is controversial and clear evidence on benefit is lacking. A thorough risk …