The term organophosphate (OP) refers to a diverse group of chemicals that are found in
hundreds of products worldwide. As pesticides, their most common use, OPs are clearly …

One of the major classes of pesticides is that of the organophosphates (OPs). Initial
developments date back almost 2 centuries but it was only in the mid-1940s that OPs …

Human pluripotent stem cell-based in vitro models that reflect human physiology have the
potential to reduce the number of drug failures in clinical trials and offer a cost-effective …

Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …

Organophosphorus (OP) nerve agents and pesticides inhibit acetylcholinesterase (AChE),
and this is thought to be a primary mechanism mediating the neurotoxicity of these …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

There is compelling evidence that adverse neurobehavioral effects are associated with
occupational organophosphorous pesticide (OP) exposure in humans. Behavioral studies of …

Epidemiological studies have observed an association between pesticide exposure and the
development of Parkinson's disease, but have not established causality. The concept of an …

Mycotoxins are key risk factors in human food and animal feed. Most of food‐origin
mycotoxins could easily enter the organism and evoke systemic toxic effects, such as …

The problem of pesticides is not new and its exposure to human due to indiscriminate use is
largely associated with the health related problems including neurotoxicological alterations …