Platinum group antitumor chemistry: design and development of new anticancer drugs complementary to cisplatin

AS Abu-Surrah, M Kettunen - Current medicinal chemistry, 2006 - ingentaconnect.com
In the next two decades, the world is expected to see around 20 million cases of cancer.
Moreover, the types of cancer will vary considerably from country to other. Therefore, all …

Furans, thiophenes and related heterocycles in drug discovery.

JB Sperry, DL Wright - Current opinion in drug discovery & …, 2005 - europepmc.org
The five-membered aromatic heterocycles containing oxygen and sulfur are key building
blocks used in medicinal chemistry applications. Furans, thiophenes and related azole …

Platinum‐based anticancer agents: Innovative design strategies and biological perspectives

YP Ho, SCF Au‐Yeung, KKW To - Medicinal research reviews, 2003 - Wiley Online Library
The impact of cisplatin on cancer chemotherapy cannot be denied. Over the past 20 years,
much effort has been dedicated to discover new platinum‐based anticancer agents that are …

Lanthanide complexes as anticancer agents: A review

NS Chundawat, S Jadoun, P Zarrintaj, NPS Chauhan - Polyhedron, 2021 - Elsevier
One of the rapidly developing fields now a days in medicine is the application of inorganic
chemistry, elegantly it is seen that the novel therapeutic and diagnostic metals and metal …

Novel bifluorescent Zn (II)–cryptolepine–cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells

ZF Wang, XF Zhou, QC Wei, QP Qin, JX Li… - European Journal of …, 2022 - Elsevier
Four novel bifluorescent Zn (II)–cryptolepine–cyclen complexes, namely [Zn (BQTC)] Cl 2
(Zn (BQTC)),[Zn (BQA)(Cur) Cl](Zn (BQACur)),[Zn (TC)] Cl 2 (Zn (TC)), and [Zn (AP)(Cur) …

In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands

JJ Wilson, SJ Lippard - Journal of medicinal chemistry, 2012 - ACS Publications
Five cationic platinum (II) complexes of general formula,[Pt (NH3) 2 (β-diketonate)] X are
reported, where X is a noncoordinating anion and β-diketonate= acetylacetonate (acac), 1 …

New copper complexes inducing bimodal death through apoptosis and autophagy in A549 cancer cells

NS Gul, TM Khan, M Chen, KB Huang, C Hou… - Journal of Inorganic …, 2020 - Elsevier
Abstract Two copper complexes, Cu1 (CuL 1 Cl 2, L 1= 2-(6, 7-dimethoxyisoquinolin-1-yl)
aniline) and Cu2 (CuL 2 Cl 2, L 2= 2-(6-methoxyisoquinolin-1-yl) aniline), were synthesized …

Novel zinc (II)− curcumin molecular probes bearing berberine and jatrorrhizine derivatives as potential mitochondria-targeting anti-neoplastic drugs

SH Zhang, ZF Wang, H Tan - European Journal of Medicinal Chemistry, 2022 - Elsevier
Berberine and jatrorrhizine are major bioactive components that are emerging as potential
anti-cancer drugs. However, no zinc (II)–berberine/jatrorrhizine–curcumin compounds have …

Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2

JL Qin, WY Shen, ZF Chen, LF Zhao, QP Qin, YC Yu… - Scientific reports, 2017 - nature.com
Three new oxoaporphine Co (II), Ni (II) and Zn (II) complexes 1–3 have been synthesized
and fully characterized. 1–3 have similar mononuclear structures with the metal and ligand …

New palladium (II) complexes bearing pyrazole-based Schiff base ligands: Synthesis, characterization and cytotoxicity

AS Abu-Surrah, KAA Safieh, IM Ahmad… - European journal of …, 2010 - Elsevier
Reactions of 5-hydrazino-1, 3-dimethyl-4-nitro-1H-pyrazole (1) with substituted
benzaldehydes (2–5) in methanol gave the new substituted benzaldehyde (1, 3-dimethyl-4 …