Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …

Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene
products mutated in Parkinson's disease, PINK1, and Parkin have been found to play a …

Alzheimer's disease (AD) is the most common form of dementia worldwide, being
characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the …

Mitochondrial fission protein 1 (Fis1) and dynamin-related protein 1 (Drp1) are the only two
proteins evolutionarily conserved for mitochondrial fission, and directly interact in …

Fission protein 1 (FIS1) and dynamin-related protein 1 (DRP1) were initially described as
being evolutionarily conserved for mitochondrial fission, yet in humans the role of FIS1 in …

Mitochondrial fission protein 1 (FIS1) is conserved in all eukaryotes, yet its function in
metazoans is thought divergent. Structure-based sequence alignments of FIS1 revealed a …

Motivation The remodeling of short fragment (s) of the protein backbone to accommodate
new function (s), fine-tune binding specificities or change/create novel protein interactions is …

The tail-anchored protein Fis1 is implicated as a passive tether in yeast mitochondrial
fission. We probed the functional role of Fis1 Glu-78, whose elevated side chain pK a …

Three-dimensional domain swapping is a mode of self-interaction that can give rise to
altered functional states and has been identified as the trigger event in some protein …

Tetratricopeptide repeat (TPR) domains are ubiquitous protein interaction domains that
adopt a modular antiparallel array of α‐helices. The TPR fold typically adopts a monomeric …