A multilayer circuit architecture for the generation of distinct locomotor behaviors in Drosophila

AA Zarin, B Mark, A Cardona, A Litwin-Kumar, CQ Doe - Elife, 2019 - elifesciences.org
Animals generate diverse motor behaviors, yet how the same motor neurons (MNs)
generate two distinct or antagonistic behaviors remains an open question. Here, we …

[HTML][HTML] Whole animal modeling: piecing together nematode locomotion

N Cohen, JE Denham - Current Opinion in Systems Biology, 2019 - Elsevier
With a reconstructed and extensively characterized neural circuit, Caenorhabditis elegans is
a fascinating model system for the study of neural circuits and behavior. Here, we review the …

Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior

V Pechuk, G Goldman, Y Salzberg, AH Chaubey… - Current biology, 2022 - cell.com
The effect of the detailed connectivity of a neural circuit on its function and the resulting
behavior of the organism is a key question in many neural systems. Here, we study the …

Novel Technological Advances in Functional Connectomics in C. elegans

EM DiLoreto, CD Chute, S Bryce… - Journal of developmental …, 2019 - mdpi.com
The complete structure and connectivity of the Caenorhabditis elegans nervous system
(“mind of a worm”) was first published in 1986, representing a critical milestone in the field of …

Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network

BG Fenyves, GS Szilágyi, Z Vassy, C Sőti… - PLoS Computational …, 2020 - journals.plos.org
Graph theoretical analyses of nervous systems usually omit the aspect of connection
polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans …

A novel and functionally diverse class of acetylcholine-gated ion channels

I Hardege, J Morud, A Courtney… - Journal of …, 2023 - Soc Neuroscience
Fast cholinergic neurotransmission is mediated by acetylcholine-gated ion channels; in
particular, excitatory nicotinic acetylcholine receptors play well established roles in virtually …

Computational inference of synaptic polarities in neuronal networks

MR Harris, TP Wytock, IA Kovács - Advanced Science, 2022 - Wiley Online Library
Synaptic polarity, that is, whether synapses are inhibitory (−) or excitatory (+), is challenging
to map, despite being a key to understand brain function. Here, synaptic polarity is inferred …

A Perspective on Information Optimality in a Neural Circuit and Other Biological Systems

R Friedman - Signals, 2022 - mdpi.com
The nematode worm Caenorhabditis elegans has a relatively simple neural system for
analysis of information transmission from sensory organ to muscle fiber. Consequently, this …

PCJ Java library as a solution to integrate HPC, Big Data and Artificial Intelligence workloads

M Nowicki, Ł Górski, P Bała - Journal of Big Data, 2021 - Springer
With the development of peta-and exascale size computational systems there is growing
interest in running Big Data and Artificial Intelligence (AI) applications on them. Big Data and …

A Drosophila larval premotor/motor neuron connectome generating two behaviors via distinct spatio-temporal muscle activity

AA Zarin, B Mark, A Cardona, A Litwin-Kumar, CQ Doe - BioRxiv, 2019 - biorxiv.org
Animals generate diverse motor behaviors, yet how the same motor neurons generate
distinct behaviors remains an open question. Drosophila larvae have multiple behaviors–eg …