Stability of protein pharmaceuticals: Recent advances
MC Manning, RE Holcomb, RW Payne… - Pharmaceutical …, 2024 - Springer
There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …
liquid state over the past years since our previous review. Our mechanistic understanding of …
Biophysical determinants for the viscosity of concentrated monoclonal antibody solutions
Monoclonal antibodies (mAbs) are particularly relevant for therapeutics due to their high
specificity and versatility, and mAb-based drugs are hence used to treat numerous diseases …
specificity and versatility, and mAb-based drugs are hence used to treat numerous diseases …
Anisotropic coarse-grain Monte Carlo simulations of lysozyme, lactoferrin, and NISTmAb by precomputing atomistic models
We develop a multiscale coarse-grain model of the NIST Monoclonal Antibody Reference
Material 8671 (NISTmAb) to enable systematic computational investigations of high …
Material 8671 (NISTmAb) to enable systematic computational investigations of high …
Electrostatically Mediated Attractive Self-Interactions and Reversible Self-Association of Fc-Fusion Proteins
Attractive self-interactions and reversible self-association are implicated in many
problematic solution behaviors for therapeutic proteins, such as irreversible aggregation …
problematic solution behaviors for therapeutic proteins, such as irreversible aggregation …
Electrostatics and viscosity are strongly linked in concentrated antibody solutions
Monoclonal antibodies are among the most promising therapeutic agents in modern
medicine, yet their formulation into high-concentration solutions for subcutaneous self …
medicine, yet their formulation into high-concentration solutions for subcutaneous self …