Roadmap: helium ion therapy

A Mairani, S Mein, E Blakely, J Debus… - Physics in Medicine …, 2022 - iopscience.iop.org
Helium ion beam therapy for the treatment of cancer was one of several developed and
studied particle treatments in the 1950s, leading to clinical trials beginning in 1975 at the …

The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research

B Faddegon, J Ramos-Méndez, J Schuemann… - Physica Medica, 2020 - Elsevier
Purpose This paper covers recent developments and applications of the TOPAS TOol for
PArticle Simulation and presents the approaches used to disseminate TOPAS. Materials and …

The 20th Gray lecture 2019: Health and heavy ions

EA Blakely - The British journal of radiology, 2020 - academic.oup.com
Objective Particle radiobiology has contributed new understanding of radiation safety and
underlying mechanisms of action to radiation oncology for the treatment of cancer, and to …

Experimental comparison of proton CT and dual energy x-ray CT for relative stopping power estimation in proton therapy

G Dedes, J Dickmann, K Niepel, P Wesp… - Physics in Medicine …, 2019 - iopscience.iop.org
Proton computed tomography (pCT) has been proposed as an alternative to x-ray computed
tomography (CT) for acquiring relative to water stopping power (RSP) maps used for proton …

A high-granularity digital tracking calorimeter optimized for proton CT

J Alme, GG Barnaföldi, R Barthel, V Borshchov… - Frontiers in …, 2020 - frontiersin.org
A typical proton CT (pCT) detector comprises a tracking system, used to measure the proton
position before and after the imaged object, and an energy/range detector to measure the …

Experimental comparison of photon versus particle computed tomography to predict tissue relative stopping powers

E Bär, L Volz, CA Collins‐Fekete, S Brons… - Medical …, 2022 - Wiley Online Library
Purpose: Measurements comparing relative stopping power (RSP) accuracy of state‐of‐the‐
art systems representing single‐energy and dual‐energy computed tomography …

The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities

L Volz, CA Collins-Fekete, E Bär, S Brons… - Physics in Medicine …, 2021 - iopscience.iop.org
This work provides a quantitative assessment of helium ion CT (HeCT) for particle therapy
treatment planning. For the first time, HeCT based range prediction accuracy in a …

Real-time PET imaging for range verification of helium radiotherapy

I Ozoemelam, E Van der Graaf, MJ Van Goethem… - Frontiers in …, 2020 - frontiersin.org
Real-time range verification of particle beams is important for optimal exploitation of the
tissue-sparing advantages of particle therapy. Positron Emission Tomography (PET) of the …

Prediction of image noise contributions in proton computed tomography and comparison to measurements

J Dickmann, P Wesp, M Rädler, S Rit… - Physics in Medicine …, 2019 - iopscience.iop.org
We present a method to accurately predict image noise in proton computed tomography
(pCT) using data generated from a Monte Carlo simulation and a patient or object model that …

Improving single-event proton CT by removing nuclear interaction events within the energy/range detector

L Volz, P Piersimoni, RP Johnson… - Physics in Medicine …, 2019 - iopscience.iop.org
Data filtering is crucial for accurate relative stopping power (RSP) reconstruction in proton
CT (pCT). In this work, we assess different filters and their performance for the US pCT …