Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants

GJ Mizejewski - Experimental biology and medicine, 2001 - journals.sagepub.com
Mammalian alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene
superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin …

Assessing protein disorder and induced folding

V Receveur‐Bréchot, JM Bourhis… - Proteins: Structure …, 2006 - Wiley Online Library
Intrinsically disordered proteins (IDPs) defy the structure–function paradigm as they fulfill
essential biological functions while lacking well‐defined secondary and tertiary structures …

[图书][B] Structure and function of intrinsically disordered proteins

P Tompa, A Fersht - 2009 - taylorfrancis.com
The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

Alpha-fetoprotein: a renaissance

AA Terentiev, NT Moldogazieva - Tumor Biology, 2013 - Springer
Alpha-fetoprotein (AFP) is a major mammalian embryo-specific and tumor-associated
protein that is also present in small quantities in adults at normal conditions. Discovery of the …

Structure and function of α-fetoprotein: a biophysical overview

JR Gillespie, VN Uversky - Biochimica et Biophysica Acta (BBA)-Protein …, 2000 - Elsevier
α-Fetoprotein (AFP) is a large serum glycoprotein belonging to the intriguing class of onco-
developmental proteins. AFP has attracted considerable attention since it was shown that …

Tumor-derived α-fetoprotein impairs the differentiation and T cell stimulatory activity of human dendritic cells

AD Pardee, J Shi, LH Butterfield - The Journal of Immunology, 2014 - journals.aai.org
Several tumor-derived factors have been implicated in dendritic cell (DC) dysfunction in
cancer patients. α-fetoprotein (AFP) is an oncofetal Ag that is highly expressed in …

Kinetic and equilibrium folding intermediates

OB Ptitsyn, VE Bychkova… - … Transactions of the …, 1995 - royalsocietypublishing.org
Our recent experiments on the molten globule state and other protein folding intermediates
lead to following conclusions:(i) the molten globule is separated by intramolecular first-order …

Rigidity of human α-fetoprotein tertiary structure is under ligand control

VN Uversky, NV Narizhneva, TV Ivanova… - Biochemistry, 1997 - ACS Publications
Comparative study of the natural ligand effect on structural properties and conformational
stability of human α-fetoprotein (AFP) and its homologue, human serum albumin (HSA), was …

Human alpha–Fetoprotein peptides bind estrogen receptor and estradiol, and suppress breast cancer

D Vakharia, GJ Mizejewski - Breast cancer research and treatment, 2000 - Springer
Alpha-fetoprotein (AFP) is a transporter of various serum ligands and regulator of cellular
growth during pregnancy. Estrogens modify AFP to exhibit growth suppressive properties …

Alpha fetoprotein is more than a hepatocellular cancer biomarker: from spontaneous immune response in cancer patients to the development of an AFP-based cancer …

R Bei, GJ Mizejewski - Current Molecular Medicine, 2011 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, with a poor
prognosis and limited therapeutic options. Due to its overexpression in the majority of HCCs …