From oxidative stress to metabolic dysfunction: The role of TRPM2
YS Li, HC Ren, H Li, M Xing, JH Cao - International Journal of Biological …, 2025 - Elsevier
Metabolic syndromes including atherosclerosis, diabetes, obesity, and hypertension are
increasingly prevalent worldwide. The disorders are the primary attributes of oxidative stress …
increasingly prevalent worldwide. The disorders are the primary attributes of oxidative stress …
Deletion of the transient receptor potential melastatin 2 gene mitigates the 6-hydroxydopamine-induced Parkinson's disease–like pathology
Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an
oxidative stress–activated calcium channel, was previously reported to be protective in …
oxidative stress–activated calcium channel, was previously reported to be protective in …
Role of the TRPM2 Channel as an ROS Sensing and Signaling Mechanism in Ischemia-Reperfusion Brain Damage
H Hou, Y Luo, J Yao, L Lu, L Ye, N Hua… - TRP-Mediated …, 2025 - taylorfrancis.com
TRPM2 is a Ca2+-permeable cation channel gated by intracellular ADP-ribose (ADPR). The
TRPM2 channel exhibits a salient sensitivity to activation by reactive oxygen species (ROS) …
TRPM2 channel exhibits a salient sensitivity to activation by reactive oxygen species (ROS) …
Hypoxia promotes temozolomide resistance in glioblastoma cells via ROS-mediated up-regulation of TRPM2
Y Cai, KY Wang, JH Chen - 2024 - researchsquare.com
Background: Hypoxia, an essential feature of gliomas, is thought to promote chemo-
resistance by regulating reactive oxygen species (ROS) levels. Transient receptor potential …
resistance by regulating reactive oxygen species (ROS) levels. Transient receptor potential …