Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

Most colon tumors develop via a multistep process involving a series of histological,
morphological, and genetic changes that accumulate over time. This has allowed for …

Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …

Abstract Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …

Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Bone morphogenetic proteins (BMPs) are a diverse class of molecules with over 20 growth
factor proteins that belong to the transforming growth factor-β (TGF-β) family and are highly …

Much of the current understanding of colorectal cancer stems from the study of rare,
inherited colorectal cancer syndromes. Mutations in the bone morphogenetic protein (BMP) …

Significant progress has been made to identify the cells at the foundation of tumorigenesis,
the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells …

Colorectal cancer is the second most common cause of cancer-related death in the United
States. Twin studies suggest that 35% of all colorectal cancer cases are inherited. High …