A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer
J Verstappe, G Berx - Seminars in Cancer Biology, 2023 - Elsevier
Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
Pancreatic cancer stem cells: A state or an entity?
PC Hermann, B Sainz Jr - Seminars in Cancer Biology, 2018 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer,
has a median overall survival of 6–12 months and a 5-year survival of less than 7%. While …
has a median overall survival of 6–12 months and a 5-year survival of less than 7%. While …
The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma
Y Fu, S Liu, S Zeng, H Shen - Molecular cancer, 2018 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases
worldwide. It is refractory to conventional treatments, and consequently has a documented 5 …
worldwide. It is refractory to conventional treatments, and consequently has a documented 5 …
[HTML][HTML] Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma
Q Wu, Y Tian, J Zhang, H Zhang, F Gu, Y Lu, S Zou… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer with
poor prognosis because it is highly resistant to traditional chemotherapy and radiotherapy …
poor prognosis because it is highly resistant to traditional chemotherapy and radiotherapy …
TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation
Pancreatic stellate cell (PSC) activation is a major event occurring during pancreatic ductal
adenocarcinoma (PDAC) development. Up to now mechanisms underlying their activation …
adenocarcinoma (PDAC) development. Up to now mechanisms underlying their activation …
Comparison of Tumour-Specific Phenotypes in Human Primary and Expandable Pancreatic Cancer Cell Lines
There is an ongoing need for patient-specific chemotherapy for pancreatic cancer. Tumour
cells isolated from human tissues can be used to predict patients' response to …
cells isolated from human tissues can be used to predict patients' response to …