Malaria vaccines: recent advances and new horizons

SJ Draper, BK Sack, CR King, CM Nielsen, JC Rayner… - Cell host & …, 2018 - cell.com
The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …

Plasmodium vivax vaccine: What is the best way to go?

GTS Veiga, MR Moriggi, JF Vettorazzi… - Frontiers in …, 2023 - frontiersin.org
Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Diagnosis of Malaria Parasites Plasmodium spp. in Endemic Areas: Current Strategies for an Ancient Disease

B Gitta, N Kilian - BioEssays, 2020 - Wiley Online Library
Fast and effective detection of the causative agent of malaria in humans, protozoan
Plasmodium parasites, is of crucial importance for increasing the effectiveness of treatment …

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

CT França, MT White, WQ He, JB Hostetler, J Brewster… - Elife, 2017 - elifesciences.org
The study of antigenic targets of naturally-acquired immunity is essential to identify and
prioritize antigens for further functional characterization. We measured total IgG antibodies …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Progress towards the development of a P. vivax vaccine

SL De, FB Ntumngia, J Nicholas… - Expert review of …, 2021 - Taylor & Francis
Introduction Plasmodium vivax causes significant public health problems in endemic
regions. A vaccine to prevent disease is critical, considering the rapid spread of drug …

Potential role of vaccines in elimination of Plasmodium vivax

M White, CE Chitnis - Parasitology International, 2022 - Elsevier
The unique biology of Plasmodium vivax, with its ability to form latent hypnozoites in the liver
stage and the early appearance of gametocytes during blood stage infection, makes it …

In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection

A Zawawi, R Forman, H Smith, I Mair, M Jibril… - PLoS …, 2020 - journals.plos.org
Trichuris trichiura is a parasite that infects 500 million people worldwide, leading to colitis,
growth retardation and Trichuris dysentery syndrome. There are no licensed vaccines …

A universal vaccine candidate against Plasmodium vivax malaria confers protective immunity against the three PvCSP alleles

AM Gimenez, AM Salman, RF Marques… - Scientific Reports, 2021 - nature.com
Malaria is a highly prevalent parasitic disease in regions with tropical and subtropical
climates worldwide. Among the species of Plasmodium causing human malaria, P. vivax is …

[HTML][HTML] CRISPR/Cas advancements for genome editing, diagnosis, therapeutics, and vaccine development for Plasmodium parasites, and genetic engineering of …

L Nourani, AA Mehrizi, S Pirahmadi… - Infection, Genetics and …, 2023 - Elsevier
Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …