Highlights•Phages use structurally diverse receptor binding proteins (RBPs) to target
different cell wall structures.•RBPs play a critical role in spatial and temporal positioning of …

The tailed double-stranded DNA bacteriophages, or Caudovirales, constitute~ 96% of all the
known phages. Although these phages come in a great variety of sizes and morphology …

Bacteriophages provide excellent tools for diagnostics, remediation, and targeted
microbiome manipulation, yet isolating viruses with suitable host specificity remains …

Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even
across membranes of neighboring cells to influence their environment, prevent predation …

Many dsDNA bacterial viruses (bacteriophages/phages) have long tail structures that serve
as organelles for DNA delivery to host targets. These structures, particularly those of …

As the importance of bacteriophages as novel antimicrobials and potential diagnostics
comes increasingly into focus, there is a heightened interest in understanding the …

The inherent ability of bacteriophages (phages) to infect specific bacterial hosts makes them
ideal candidates to develop into antimicrobial agents for pathogen-specific remediation in …

Most bacteriophages present a tail allowing host recognition, cell wall perforation, and viral
DNA channeling from the capsid to the infected bacterium cytoplasm. The majority of tailed …

The first step in bacteriophage infection is recognition and binding to the host receptor,
which is mediated by the phage receptor binding protein (RBP). Different RBPs can lead to …

The phage life cycle is a multi-stage process initiated by the recognition and attachment of
the virus to its bacterial host. This adsorption step depends on the specific interaction …