[HTML][HTML] Triple negative breast cancer: the kiss of death

AA Jitariu, AM Cîmpean, D Ribatti, M Raica - Oncotarget, 2017 - ncbi.nlm.nih.gov
One of the most controversial women malignancies, triple negative breast cancers (TNBCs)
are critically overviewed here, being focused on data useful in clinical practice or to improve …

Stress and the emerging roles of chromatin remodeling in signal integration and stable transmission of reversible phenotypes

ICG Weaver, AC Korgan, K Lee, RV Wheeler… - Frontiers in Behavioral …, 2017 - frontiersin.org
The influence of early life experience and degree of parental-infant attachment on emotional
development in children and adolescents has been comprehensively studied. Structural and …

ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells

D Vidovic, TT Huynh, P Konda, C Dean… - Cell Death & …, 2020 - nature.com
To discover novel therapeutic targets for triple-negative breast cancer (TNBC) and cancer
stem cells (CSCs), we screened long non-coding RNAs (lncRNAs) most enriched in TNBCs …

Genetic mutations and epigenetic modifications: driving cancer and informing precision medicine

KM Coyle, JE Boudreau… - BioMed research …, 2017 - Wiley Online Library
Cancer treatment is undergoing a significant revolution from “one‐size‐fits‐all” cytotoxic
therapies to tailored approaches that precisely target molecular alterations. Precision …

Reporters of cancer stem cells as a tool for drug discovery

A Mohan, R Raj R, G Mohan, P KP… - Frontiers in …, 2021 - frontiersin.org
In view of the importance of cancer stem cells (CSCs) in chemoresistance, metastasis and
recurrence, the biology of CSCs were explored in detail. Based on that, several modalities …

ALDH1A3 is the switch that determines the balance of ALDH+ and CD24CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer

W Fernando, BM Cruickshank, RP Arun, MR MacLean… - Oncogene, 2024 - nature.com
Plasticity is an inherent feature of cancer stem cells (CSCs) and regulates the balance of key
processes required at different stages of breast cancer progression, including epithelial-to …

Decitabine response in breast cancer requires efficient drug processing and is not limited by multidrug resistance

ML Dahn, BM Cruickshank, AJ Jackson, C Dean… - Molecular cancer …, 2020 - AACR
Dysregulation of DNA methylation is an established feature of breast cancers. DNA
demethylating therapies like decitabine are proposed for the treatment of triple-negative …

[HTML][HTML] GAPDH and PUM1: optimal housekeeping genes for quantitative polymerase chain reaction-based analysis of cancer stem cells and epithelial-mesenchymal …

L Vermani, R Kumar, NS Kumar - Cureus, 2020 - ncbi.nlm.nih.gov
Background The overwhelming majority of published articles have taken colon and rectal
cancer as a single group, ie, colorectal cancer, when normalizing gene expression data with …

[HTML][HTML] Cognitive decline, cerebral-spleen tryptophan metabolism, oxidative stress, cytokine production, and regulation of the txnip gene in a triple transgenic mouse …

E Fertan, GJ Rodrigues, RV Wheeler, D Goguen… - The American Journal of …, 2019 - Elsevier
Pathologic inflammation in response to injury, infection, or oxidative stress is a proposed
mechanism relating cognitive decline to dementia. The kynurenine pathway and thioredoxin …

Tumor suppressor RARRES1-A novel regulator of fatty acid metabolism in epithelial cells

S Maimouni, N Issa, S Cheng, C Ouaari, A Cheema… - PloS one, 2018 - journals.plos.org
Retinoic acid receptor responder 1 (RARRES1) is silenced in many cancers and is
differentially expressed in metabolism associated diseases, such as hepatic steatosis …