Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly
expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor …

Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are
associated with Alzheimer's disease (AD). Starting from an unbiased protein microarray …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …

Neurodegenerative diseases of the central nervous system progressively rob patients of
their memory, motor function, and ability to perform daily tasks. Advances in genetics and …

Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of
death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β …

Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …

Several heterozygous missense mutations in the triggering receptor expressed on myeloid
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders …