Interindividual differences in caffeine metabolism and factors driving caffeine consumption

A Nehlig - Pharmacological reviews, 2018 - ASPET
Most individuals adjust their caffeine intake according to the objective and subjective effects
induced by the methylxanthine. However, to reach the desired effects, the quantity of …

Prospective therapeutic potential of Tanshinone IIA: An updated overview

MA Ansari, FB Khan, HA Safdari, A Almatroudi… - Pharmacological …, 2021 - Elsevier
In the past decades, the branch of complementary and alternative medicine based
therapeutics has gained considerable attention worldwide. Pharmacological efficacy of …

Caffeine consumption through coffee: Content in the beverage, metabolism, health benefits and risks

J dePaula, A Farah - Beverages, 2019 - mdpi.com
Caffeine (1, 3, 7-trimethylxanthine) is the most consumed psychoactive substance in the
world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is …

Cardiovascular actions and therapeutic potential of tanshinone IIA

S Gao, Z Liu, H Li, PJ Little, P Liu, S Xu - Atherosclerosis, 2012 - Elsevier
Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the
Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian …

Pharmacokinetics and metabolism of natural methylxanthines in animal and man

BB Fredholm, MJ Arnaud - Methylxanthines, 2011 - Springer
Caffeine, theophylline, theobromine, and paraxanthine administered to animals and humans
distribute in all body fluids and cross all biological membranes. They do not accumulate in …

Tanshinones: sources, pharmacokinetics and anti-cancer activities

Y Zhang, P Jiang, M Ye, SH Kim, C Jiang… - International journal of …, 2012 - mdpi.com
Tanshinones are a class of abietane diterpene compound isolated from Salvia miltiorrhiza
(Danshen or Tanshen in Chinese), a well-known herb in Traditional Chinese Medicine …

Pharmacokinetics of caffeine: A systematic analysis of reported data for application in metabolic phenotyping and liver function testing

J Grzegorzewski, F Bartsch, A Köller… - Frontiers in …, 2022 - frontiersin.org
Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa,
energy drinks, and many other beverages and food. Caffeine is almost exclusively …

[HTML][HTML] Sodium tanshinone IIA sulfonate: a review of pharmacological activity and pharmacokinetics

ZY Zhou, WR Zhao, J Zhang, XL Chen… - Biomedicine & …, 2019 - Elsevier
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA)
which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza …

Nrf2‑dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin‑induced cardiotoxicity

Z Guo, M Yan, L Chen, P Fang, Z Li… - Experimental and …, 2018 - spandidos-publications.com
Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe
cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid …

[HTML][HTML] A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment

Z Bi, Y Wang, W Zhang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract Tanshinone IIA (Tan IIA) is the most abundant lipid-soluble component in Salvia
miltiorrhiza. Both Tan IIA and its derivatives including Sodium tanshinone IIA sulfonate (STS) …