Malaria vaccines: recent advances and new horizons

SJ Draper, BK Sack, CR King, CM Nielsen, JC Rayner… - Cell host & …, 2018 - cell.com
The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …

Malaria vaccines since 2000: progress, priorities, products

PE Duffy, J Patrick Gorres - npj Vaccines, 2020 - nature.com
Malaria vaccine development entered a new era in 2015 when the pre-erythrocytic
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …

Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …

Controlled human malaria infection: applications, advances, and challenges

DI Stanisic, JS McCarthy, MF Good - Infection and immunity, 2018 - Am Soc Microbiol
Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

Sporozoite immunization: innovative translational science to support the fight against malaria

TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

The immunology of Plasmodium vivax malaria

LR Antonelli, C Junqueira, JM Vinetz… - Immunological …, 2020 - Wiley Online Library
Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

Plasmodium vivax vaccine: What is the best way to go?

GTS Veiga, MR Moriggi, JF Vettorazzi… - Frontiers in …, 2023 - frontiersin.org
Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools

C Schäfer, G Zanghi, AM Vaughan… - Annual Review of …, 2021 - annualreviews.org
Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

KE Swearingen, SE Lindner, EL Flannery… - PLoS neglected …, 2017 - journals.plos.org
Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases.
Research efforts predominantly focus on P. falciparum because of the clinical severity of …