The evolution, function and mechanisms of action for plant defensins

K Parisi, TMA Shafee, P Quimbar… - Seminars in cell & …, 2019 - Elsevier
Plant defensins are an extensive family of small cysteine rich proteins characterised by a
conserved cysteine stabilised alpha beta protein fold which resembles the structure of insect …

[HTML][HTML] Membrane-interacting antifungal peptides

C Struyfs, BPA Cammue, K Thevissen - Frontiers in cell and …, 2021 - frontiersin.org
The incidence of invasive fungal infections is increasing worldwide, resulting in more than
1.6 million deaths every year. Due to growing antifungal drug resistance and the limited …

[HTML][HTML] Plant defensins from a structural perspective

V Kovaleva, I Bukhteeva, OY Kit… - International Journal of …, 2020 - mdpi.com
Plant defensins form a family of proteins with a broad spectrum of protective activities
against fungi, bacteria, and insects. Furthermore, some plant defensins have revealed …

Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects

AA Baxter, FT Lay, IKH Poon, M Kvansakul… - Cellular and Molecular …, 2017 - Springer
There is an ongoing need for effective and targeted cancer treatments that can overcome the
detrimental side effects presented by current treatment options. One class of novel …

Antifungal plant defensins: increased insight in their mode of action as a basis for their use to combat fungal infections

TL Cools, C Struyfs, BPA Cammue… - Future …, 2017 - Taylor & Francis
Plant defensins are small, cationic peptides with a highly conserved 3D structure. They have
been studied extensively in the past decades. Various biological activities have been …

[HTML][HTML] Salt-tolerant antifungal and antibacterial activities of the corn defensin ZmD32

BK Kerenga, JA McKenna, PJ Harvey… - Frontiers in …, 2019 - frontiersin.org
Pathogenic microbes are developing resistance to established antibiotics, making the
development of novel antimicrobial molecules paramount. One major resource for discovery …

[HTML][HTML] X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex

M Järvå, FT Lay, TK Phan, C Humble, IKH Poon… - Nature …, 2018 - nature.com
Defensins are cationic antimicrobial peptides expressed throughout the plant and animal
kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is …

[HTML][HTML] Hyperpolarisation of mitochondrial membranes is a critical component of the antifungal mechanism of the plant defensin, Ppdef1

K Parisi, JA McKenna, R Lowe, KS Harris, T Shafee… - Journal of Fungi, 2024 - mdpi.com
Plant defensins are a large family of small cationic proteins with diverse functions and
mechanisms of action, most of which assert antifungal activity against a broad spectrum of …

[HTML][HTML] The plant defensin Ppdef1 is a novel topical treatment for onychomycosis

NL van der Weerden, K Parisi, JA McKenna, BM Hayes… - Journal of Fungi, 2023 - mdpi.com
Onychomycosis, or fungal nail infection, causes not only pain and discomfort but can also
have psychological and social consequences for the patient. Treatment of onychomycosis is …

Membrane binding properties of plant defensins

M Shahmiri, MR Bleackley, CS Dawson… - Phytochemistry, 2023 - Elsevier
The membrane interaction characteristics of five antifungal plant defensin peptides: NaD1,
and the related HXP4 and L5, as well as NaD2 and the related ZmD32 were studied. These …