Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

Regulatory B cells (Bregs) modulate immune responses predominantly, although not
exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Over the last decade it has become evident that in addition to producing antibody, B cells
activate the immune system by producing cytokines and via antigen presentation. In …

The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …

Primary Sjögren syndrome (pSS) is a progressive autoimmune disease characterized by
sicca and systemic manifestations. In this Review, we summarize the available data on …

Equivalent to regulatory T cells, a novel B cell populace, called regulatory B cells (Bregs),
has been found to exert a negative immune regulatory role. These subsets of cells account …