Role of sleep deprivation in immune-related disease risk and outcomes

S Garbarino, P Lanteri, NL Bragazzi… - Communications …, 2021 - nature.com
Modern societies are experiencing an increasing trend of reduced sleep duration, with
nocturnal sleeping time below the recommended ranges for health. Epidemiological and …

Rationale for a multi-factorial approach for the reversal of cognitive decline in Alzheimer's disease and MCI: a review

RV Rao, KG Subramaniam, J Gregory… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease
typically characterized by memory loss, personality changes, and a decline in overall …

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

SB Chidambaram, MM Essa, AG Rathipriya… - Pharmacology & …, 2022 - Elsevier
The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

Glymphatic system dysfunction and sleep disturbance may contribute to the pathogenesis and progression of Parkinson's disease

A Massey, MK Boag, A Magnier, DPCF Bispo… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

Melatonin–Microbiome two-sided interaction in Dysbiosis-associated conditions

MI Iesanu, CDM Zahiu, IA Dogaru, DM Chitimus… - Antioxidants, 2022 - mdpi.com
Melatonin is a pineal indolamine, allegedly known as a circadian rhythm regulator, and an
antioxidative and immunomodulatory molecule. In both experimental and clinical trials …

Multiple sclerosis: inflammatory and neuroglial aspects

G Papiri, G D'Andreamatteo, G Cacchiò, S Alia… - Current Issues in …, 2023 - mdpi.com
Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …

Sleep deprivation-induced oxidative stress in rat models: a scoping systematic review

VS Neculicioiu, IA Colosi, C Costache, DA Toc… - Antioxidants, 2023 - mdpi.com
Sleep deprivation is highly prevalent in the modern world, possibly reaching epidemic
proportions. While multiple theories regarding the roles of sleep exist (inactivity, energy …

Brain mechanisms of COVID-19-sleep disorders

O Semyachkina-Glushkovskaya, A Mamedova… - International Journal of …, 2021 - mdpi.com
2020 and 2021 have been unprecedented years due to the rapid spread of the modified
severe acute respiratory syndrome coronavirus around the world. The coronavirus disease …

Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing

M Shimada, Y Omae, A Kakita, R Gabdulkhaev… - Science …, 2024 - science.org
In neurological and neuropsychiatric diseases, different brain regions are affected, and
differences in gene expression patterns could potentially explain this mechanism. However …

Sleep deprivation and gut microbiota dysbiosis: current understandings and implications

J Sun, D Fang, Z Wang, Y Liu - International Journal of Molecular …, 2023 - mdpi.com
Gut microbiota comprises the microbial communities inhabiting our gastrointestinal (GI)
tracts. Accordingly, these complex communities play a fundamental role in many host …