Cholesterol is an essential component of cell membranes and the precursor for the
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …

The mevalonate pathway accounts for conversion of acetyl-CoA to isopentenyl 5-
diphosphate, the versatile precursor of polyisoprenoid metabolites and natural products. The …

Importance Linear porokeratosis features linear and whorled configurations of keratotic
papules and plaques, with coronoid lamellae present on histologic examination. Because …

The sea cucumber Apostichopus japonicus is one of the most dominant and economically
important aquaculture species in China. Saponin, which possesses notable biological and …

Phosphomevalonate kinase (PMK) is an important enzyme involved in the juvenile hormone
(JH) biosynthesis pathway that catalyzes the phosphorylation of mevalonate 5-phosphate …

In Trypanosoma cruzi the isoprenoid and sterol biosynthesis pathways are validated targets
for chemotherapeutic intervention. In this work we present a study of the genetic diversity …

Background In the isoprenoid biosynthesis pathway, mevalonate is phosphorylated in two
subsequent enzyme steps by mevalonate kinase (MVK) and phosphomevalonate kinase …

Cholesterol biosynthesis, primarily associated with eukaryotes, occurs as an essential
component of human metabolism with biosynthetic deregulation a factor in cancer viability …

Type I DNA methyltransferases contain one specificity subunit (HsdS) and two modification
subunits (HsdM). The electron microscopy model of M. EcoKI-M2S1 methyltransferase …

The evolutionarily conserved mevalonate pathway plays an important role in the synthesis of
cholesterol and isoprenoid compounds. Mevalonate kinase (MVK) and phosphomevalonate …