Cocrystal engineering of pharmaceutical solids: Therapeutic potential and challenges

SN Wong, YCS Chen, B Xuan, CC Sun, SF Chow - CrystEngComm, 2021 - pubs.rsc.org
Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Recent advances in co-processed APIs and proposals for enabling commercialization of these transformative technologies

L Schenck, D Erdemir, L Saunders Gorka… - Molecular …, 2020 - ACS Publications
Optimized physical properties (eg, bulk, surface/interfacial, and mechanical properties) of
active pharmaceutical ingredients (APIs) are key to the successful integration of drug …

The seventh blind test of crystal structure prediction: structure generation methods

LM Hunnisett, J Nyman, N Francia, NS Abraham… - Structural …, 2024 - journals.iucr.org
A seventh blind test of crystal structure prediction was organized by the Cambridge
Crystallographic Data Centre featuring seven target systems of varying complexity: a silicon …

Sustainable preparation of spherical particles of novel carbamazepine-hesperetin cocrystal via different crystallization strategies: From mechanism to application

L Liu, S Wang, J Ouyang, M Chen, L Zhou, Z Liu… - Separation and …, 2023 - Elsevier
Spherical crystallization is widely employed in pharmaceutical industry to produce spherical
particles that exhibit improved micrometric performances of active pharmaceutical …

Discovered two polymorphs and two solvates of lamotrigine-tolfenamic acid salt: Thermal behavior and crystal morphological differences

J Li, Y Huang, Q An, W Li, J Li, H Liu, D Yang… - International Journal of …, 2022 - Elsevier
Multi-component pharmaceutical systems such as cocrystal and salt have gained popularity
in academia and industry due to their ability to regulate the poor physicochemical properties …

Design of spherical agglomerates via crystallization with a non-toxic bridging liquid: From mechanism to application

S Guo, S Feng, C Yu, Y Liu, K Li, M Chen, D Han… - Powder Technology, 2022 - Elsevier
The cooling crystallization-spherical agglomeration (CCSA) technology proposed in this
work overcomes the disadvantages of complex process and biohazardous solvents, which …

Spherical particles design of vanillin via crystallization method: Preparation, characterization and mechanism

X Xing, J Ouyang, S Guo, M Chen, Z Gao, F He… - Separation and …, 2023 - Elsevier
Vanillin is a natural flavor and is widely used in the fields of medicine, food and
optoelectronics. However, the stable form I of vanillin usually shows needle or fiber-like …

Design of the spherical agglomerate size in crystallization by developing a two‐step bridging mechanism and the model

C Yu, M Yao, Y Ma, Y Liu, S Guo, S Xu… - AIChE …, 2022 - Wiley Online Library
Spherical agglomeration technology can produce high‐performance spherical particles in a
single crystallization unit, although it is still challenging to control the particle size and …

Novel drug-drug salts of enoxacin with enhanced antibacterial activity: Insights from solubility and lipid-water partition coefficient

J Li, S Song, W Huang, H Fan, Z Zhou - Journal of Molecular Liquids, 2023 - Elsevier
Abstract Enoxacin (ENX), a third-generation fluoroquinolone, demonstrates broad-spectrum
antibacterial activities and is widely applied for the treatment of various bacterial infections …

Microstructures and pharmaceutical properties of ferulic acid agglomerates prepared by different spherical crystallization methods

H Chen, C Wang, H Kang, B Zhi, CL Haynes… - International journal of …, 2020 - Elsevier
Spherical agglomerates of an active pharmaceutical ingredient, ferulic acid (FA), were
prepared using four different spherical crystallization methods, ie, quasi-emulsion solvent …