Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …

The molecular basis of the earliest neuronal changes that lead to Alzheimer's disease (AD)
is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene …

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …

Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ
fragments of APP are the major constituent of AD-associated amyloid plaques, and …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …

While a massive and progressive neuronal loss in specific areas such as the hippocampus
and cortex unequivocally underlies cognitive deterioration and memory loss in Alzheimer's …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …

The processing of amyloid precursor protein (APP) to Aβ is an important event in the
pathogenesis of Alzheimer's disease, but the physiological function of APP is not well …