Cerebral cavernous malformations (CCM s) are vascular malformations located within the
central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is …

Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and
generation of spermatogonia committed to differentiation. Under certain in vitro conditions …

Purpose MicroRNAs (miRNAs) are small non-coding RNA molecules that have been
identified as potent regulators of gene expression. Recent studies indicate that miRNAs are …

Ductal pancreatic carcinoma (DPC) is a deadly disease with an incidence of 9 cases in
100,000 people per year and a mortality rate close to 100%. Allelic losses in the long arm of …

The Kruppel-like factor family is a group of zinc finger containing transcription factors, which
are highly homologous with the Drosophila Kruppel protein. The feature that distin‐-guishes …

Porcine induced pluripotent stem cells (piPSCs) have the capacity to differentiate in vitro and
in vivo and form chimeras. However, the lack of transgene silencing of exogenous DNA …

OBJECTIVE: KLF4 and KLF5, members of the Krüppel-like factor (KLF) family, play key roles
in proliferation, differentiation and apoptosis during development. In order to determine if …

A hallmark of male germ cell gene expression is the generation by alternative
polyadenylation of cell-specific mRNAs, many of which utilize noncanonical A (A/U) UAAA …

Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor critically involved in cell
proliferation, differentiation, and carcinogenesis. Recently, KLF4 was also used for the …

Krüppel-like factor 4 (KLF4) is a pleiotropic zinc finger transcription factor that regulates
genes being involved in differentiation and cell-cycle control. Knockout studies revealed a …