Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …

Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

Importance The placebo effect in depression clinical trials is a substantial factor associated
with failure to establish efficacy of novel and repurposed treatments. However, the …

Background: Major depressive disorder (MDD) is a highly burdensome health condition, for
which there are numerous accepted pharmacological and psychological interventions …

Objectives Rapid cycling is a common and disabling phenomenon in individuals with bipolar
disorders. In the absence of a recent literature examination, this systematic review and meta …

Background Despite well-established guidelines for managing major depressive disorder,
its extensive disability burden persists. This Value of Treatment mission from the European …

BackgroundRandomised controlled trials (RCTs) of psilocybin have reported large
antidepressant effects in adults with major depressive disorder and treatment-resistant …

Importance Immune-metabolic disturbances have been implicated in the pathophysiology of
major depressive disorder and may be more prominent in individuals with treatment …

Background With the emergence of evidence-based treatments for treatment-resistant
depression, strategies to identify individuals at greater risk for treatment resistance early in …