Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a
cascade of intracellular components that mediate its effects, plays a major role in the …

The notion of'the human'is in need of urgent redefinition. At a time of radical bio-
technological developments, and in light of the political and environmental imperatives of …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle
growth and repair through replacement of damaged myofibers. Muscle regeneration is …

Current molecular genomic approaches to human genetic disorders have led to an
explosion in the identification of the genes and their encoded proteins responsible for these …

Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

Adult skeletal muscle can regenerate in response to muscle damage. This ability is
conferred by the presence of myogenic stem cells called satellite cells. In response to stimuli …

Cachexia causes weight loss and increased mortality. It affects more than 5 million persons
in the United States. Other causes of weight loss include anorexia, sarcopenia, and …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …