Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's
disease (AD), suggesting that activation of this innate immune receptor may be a useful …

Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …

Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Microglia play a critical role in brain homeostasis and disease progression. In
neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD) …

Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …