Cell penetrating peptides: the potent multi-cargo intracellular carriers

K Kardani, A Milani, S H. Shabani… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

Improvements in chemical carriers of proteins and peptides

A Bolhassani - Cell Biology International, 2019 - Wiley Online Library
The successful intracellular delivery of biologically active proteins and peptides plays an
important role for therapeutic applications. Indeed, protein/peptide delivery could overcome …

A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

X Zhao, Y Zhang, O Trejo-Cerro, E Kaplan, Z Li… - npj Vaccines, 2024 - nature.com
Persistent infection with high-risk human papillomavirus (HPV) is widely recognized as the
primary cause of cervical and other malignant cancers. There are six licensed prophylactic …

Transport Oligonucleotides—A Novel System for Intracellular Delivery of Antisense Therapeutics

OV Markov, AV Filatov, MS Kupryushkin, IV Chernikov… - Molecules, 2020 - mdpi.com
Biological activity of antisense oligonucleotides (asON), especially those with a neutral
backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept …

Emerging Landscape of Supercharged Proteins and Peptides for Drug Delivery

L Wang, J Geng, H Wang - ACS Pharmacology & Translational …, 2024 - ACS Publications
Although groundbreaking biotechnological techniques such as gene editing have
significantly progressed, the effective and targeted transport of therapeutic agents into host …

Comparison of HIV-1 Vif and Vpu accessory proteins for delivery of polyepitope constructs harboring Nef, Gp160 and P24 using various cell penetrating peptides

K Kardani, A Hashemi, A Bolhassani - PLoS One, 2019 - journals.plos.org
To develop an effective therapeutic vaccine against HIV-1, prediction of the most conserved
epitopes derived from major proteins using bioinformatics tools is an alternative …

B1 protein: a novel cell penetrating protein for in vitro and in vivo delivery of HIV-1 multi-epitope DNA constructs

K Kardani, A Bolhassani, E Agi, A Hashemi - Biotechnology Letters, 2020 - Springer
Objectives Enhancement of the potential ability of biomacromolecules to cross cell
membranes is a critical step for development of effective therapeutic vaccine especially DNA …

Antitumor Effects of HPV E7 and L1-E7 Multiepitope DNA Constructs Delivered by Synthetic and Arginine-Rich Cell Penetrating Peptides

N Fathi, A Hojaji, A Bolhassani, E Agi - International Journal of Peptide …, 2025 - Springer
Non-viral delivery systems such as cell penetrating peptides (CPPs) complexed with
therapeutic agents have shown promising results through increased cellular uptake of …

Enhanced gene delivery in tumor cells using chemical carriers and mechanical loadings

A Hadi, A Rastgoo, N Haghighipour, A Bolhassani… - Plos one, 2018 - journals.plos.org
Intracellular delivery of DNA is considered a challenge in biological research and treatment
of diseases. The previously reported transfection rate by commercially available transfection …

Development of Delivery Systems Enhances the Potency of Cell‐Based HIV‐1 Therapeutic Vaccine Candidates

A Hadi, A Rastgoo, M Eskandarian… - Journal of …, 2021 - Wiley Online Library
An effective therapeutic vaccine to eradicate HIV‐1 infection does not exist yet. Among
different vaccination strategies, cell‐based vaccines could achieve in clinical trials. Cell …