Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

The increase in the prevalence of obesity represents a worldwide phenomenon in all age
groups and is pathologically and genetically correlated with several metabolic and …

In the last decades, autoimmune diseases have experienced a dramatic increase in Western
countries. The involvement of environmental factors is strongly suspected to explain this rise …

Osteoarthritis (OA) has long been considered a “wear and tear” disease leading to loss of
cartilage. OA used to be considered the sole consequence of any process leading to …

Mesenchymal stem cells (MSCs) have been proven to have superior potential to be used as
therapeutic candidates in various disorders. Nevertheless, the clinical application of these …

Psoriasis is a common chronic inflammatory skin disease with a complex pathogenesis
consisting of a genetic component, immune dysfunction, and environmental factors. It is …

Osteoarthritis (OA) is the most prevalent chronic rheumatic diseases worldwide, with a
strong impact on individual and population health. OA is a clinically heterogeneous disease …