Transcriptome-wide association studies: recent advances in methods, applications and available databases
Genome-wide association study has identified fruitful variants impacting heritable traits.
Nevertheless, identifying critical genes underlying those significant variants has been a …
Nevertheless, identifying critical genes underlying those significant variants has been a …
Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations
M Elgart, G Lyons, S Romero-Brufau… - Communications …, 2022 - nature.com
Polygenic risk scores (PRS) are commonly used to quantify the inherited susceptibility for a
trait, yet they fail to account for non-linear and interaction effects between single nucleotide …
trait, yet they fail to account for non-linear and interaction effects between single nucleotide …
Protein prediction for trait mapping in diverse populations
R Schubert, E Geoffroy, I Gregga, AJ Mulford, F Aguet… - PLoS …, 2022 - journals.plos.org
Genetically regulated gene expression has helped elucidate the biological mechanisms
underlying complex traits. Improved high-throughput technology allows similar interrogation …
underlying complex traits. Improved high-throughput technology allows similar interrogation …
Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients
Background Previous investigations of transcriptomic signatures of cancer patient survival
and post-therapy relapse have focused on tumor tissue. In contrast, here we show that in …
and post-therapy relapse have focused on tumor tissue. In contrast, here we show that in …
Regulome‐wide association study identifies genetically driven accessible regions associated with pancreatic cancer risk
Genome‐wide association studies (GWAS) have identified two dozen genetic variants that
are associated with the risk of pancreatic ductal adenocarcinoma (PDAC), a deadly …
are associated with the risk of pancreatic ductal adenocarcinoma (PDAC), a deadly …
[HTML][HTML] Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations
Transcriptome prediction models built with data from European-descent individuals are less
accurate when applied to different populations because of differences in linkage …
accurate when applied to different populations because of differences in linkage …
Artificial Intelligence and Computational Biology in Gene Therapy: A Review
M Danaeifar, A Najafi - Biochemical Genetics, 2024 - Springer
One of the trending fields in almost all areas of science and technology is artificial
intelligence. Computational biology and artificial intelligence can help gene therapy in many …
intelligence. Computational biology and artificial intelligence can help gene therapy in many …
Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines
Population-level genetic studies are overwhelmingly biased toward European ancestries.
Transferring genetic predictions from European ancestries to other ancestries results in a …
Transferring genetic predictions from European ancestries to other ancestries results in a …
Statistical power of transcriptome‐wide association studies
Abstract Transcriptome‐Wide Association Studies (TWASs) have become increasingly
popular in identifying genes (or other endophenotypes or exposures) associated with …
popular in identifying genes (or other endophenotypes or exposures) associated with …
Accounting for nonlinear effects of gene expression identifies additional associated genes in transcriptome-wide association studies
Z Lin, H Xue, MM Malakhov… - Human molecular …, 2022 - academic.oup.com
Transcriptome-wide association studies (TWAS) integrate genome-wide association study
(GWAS) data with gene expression (GE) data to identify (putative) causal genes for complex …
(GWAS) data with gene expression (GE) data to identify (putative) causal genes for complex …