Ramachary-Bressy-Wang [3+ 2] cycloaddition reaction: Synthesis of fully decorated 1, 2, 3-triazoles as potent anticancer and EGFR inhibitors

M Kumar, SK Nukala, NS Thirukovela… - Journal of Molecular …, 2022 - Elsevier
A general strategy was developed for the synthesis of new fully decorated 1, 2, 3-triazoles
(5a-m & 6a-e) containing coumarine and sulfonyl-benzimidazole from 3-(2-((1-methyl-1H …

Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents

SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Synthesis and biological evaluation of coumarine-imidazo [1, 2-c][1, 2, 3] triazoles: PEG-400 mediated one-pot reaction under ultrasonic irradiation

R Samala, SK Nukala, R Manchal, VR Nagavelli… - Journal of Molecular …, 2023 - Elsevier
Synthetic chemists have organized easy and effective ways for perfect synthesis in response
to the requirement for scaffolds that are crucial for medical applications. To investigate the …

The anti‐breast cancer therapeutic potential of 1, 2, 3‐triazole‐containing hybrids

J Song, S Zhang, B Zhang, J Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …

Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents

SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

Cu(I)‐Catalyzed One‐Pot Synthesis of [1,2,3]Triazolo[5,1‐a] isoquinolin‐6(5H)‐one Derivatives as EGFR‐Targeting Anticancer Agents

R Samala, S Kumar Nukala… - …, 2022 - Wiley Online Library
The CuI promoted one‐pot multi‐component synthesis of new fused [1, 2, 3] triazolo [5, 1‐a]
isoquinoline derivatives (4 a–4 h, 8 a–8 f & 9 a–9 f) without isolating unsafe azides and their …

Synthesis and Biological Evaluation of Benzo [d] thiazolyl‐Sulfonyl‐Benzo [4, 5] isothiazolo [2, 3‐c][1, 2, 3] triazole Derivatives as EGFR Targeting Anticancer Agents

E Ramya Sucharitha, S Kumar Nukala… - …, 2023 - Wiley Online Library
A one‐step procedure for the synthesis of new fused Benzo [d] thiazolo‐1, 2, 3‐triazoles (3 a–
3 h and 4 a–4 h) in good yields using sulfonylazides (2) and iodoalkyne (1) through from the …

One-pot synthesis, anticancer, EGFR and caspases assays of novel fused [1, 2, 3] triazolo-pyrrolo [2, 1-b] quinazolinones

N Udayasree, RB Haridasyam, R Palabindela… - Journal of Molecular …, 2025 - Elsevier
In this study, we designed and synthesized several novel fused [1, 2, 3] triazolo [4′, 5′: 3,
4] pyrrolo [2, 1-b] quinazolinone derivatives using a single [3+ 2] reaction cycloaddition …

Recent Developments in Isoindole Chemistry

RA Weintraub, X Wang - Synthesis, 2023 - thieme-connect.com
Isoindoles are highly reactive aromatic heterocycles that have a variety of important
applications in areas such as medicine, analytical detection, and solar energy. Due to their …

Organocatalytic [3+ 2] Cycloaddition reaction: synthesis of fully decorated sulfonyl-1, 2, 3-triazolyl pyrimidines as potent anticancer and EGFR inhibitors

JMR Velidandla, SK Koppula - Polycyclic Aromatic Compounds, 2024 - Taylor & Francis
A general strategy was developed for the synthesis of new fully decorated sulfonyl1, 2, 3-
triazolyl pyrimidines (6a–6j and 8a–8f) from 2-((6-methyl-2-(methylsulfonyl) pyrimidin-4-yl) …