Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Among cells present in the tumor microenvironment, activated fibroblasts termed cancer-
associated fibroblasts (CAFs), play a critical role in the complex process of tumor-stroma …

Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in
the tumor microenvironment, leading to immunosuppressive features. Here, we employed …

Increasing lines of evidence show that the malignant behavior of cancer is not exclusively
attributable to cancer cells but also radically influenced by cancerous stroma activity and …

Abstract Background Mesenchymal stromal cells (MSCs) are multipotent progenitor cells
used in several cell therapies. MSCs are characterized by the expression of CD73, CD90 …

Reactive stroma initiates during early prostate cancer development and coevolves with
prostate cancer progression. Previous studies have defined the key markers of reactive …

The microenvironment of established tumours is often immunosuppressed, and this allows
tumours to grow and disseminate without being eliminated by the patient's immune system …

The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …

Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this
cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the …

Anchored cells of the basal epidermis constantly undergo proliferation in an overcrowded
environment. An important regulator of epidermal proliferation is YAP, which can be …