De novo metalloprotein design

MJ Chalkley, SI Mann, WF DeGrado - Nature Reviews Chemistry, 2022 - nature.com
Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

Ruthenium complexes as promising candidates against lung cancer

Q Sun, Y Li, H Shi, Y Wang, J Zhang, Q Zhang - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common malignancies with the highest mortality rate and the
second-highest incidence rate after breast cancer, posing a serious threat to human health …

Rhodium (III)–Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy

YQ Gu, K Yang, QY Yang, HQ Li, MQ Hu… - Journal of Medicinal …, 2023 - ACS Publications
As a continuation of our endeavors in discovering metal-based drugs with cytotoxic and
antimetastatic activities, herein, we reported the syntheses of 11 new rhodium (III) …

[HTML][HTML] C–H bond functionalization reactions enabled by photobiocatalytic cascades

Y Li, B Yuan, Z Sun, W Zhang - Green Synthesis and Catalysis, 2021 - Elsevier
Light may participate in biocatalytic processes either by direct light-induced biocatalysis or
by cascading light-induced chemical reactions with biocatalytic ones, which are …

Metal‐mediated functionalization of natural peptides and proteins: Panning for bioconjugation gold

J Ohata, SC Martin, ZT Ball - Angewandte Chemie International …, 2019 - Wiley Online Library
Selective modification of natural proteins is a daunting methodological challenge and a
stringent test of selectivity and reaction scope. There is a continued need for new reactivity …

Dirhodium (II, II) paddlewheel complexes

R Hrdina - European Journal of Inorganic Chemistry, 2021 - Wiley Online Library
This minireview summarizes synthetic approaches towards homoleptic dirhodium (II, II)
paddlewheel complexes with the general formula Rh2A4. These complexes have found …

Organometallic S-arylation Reagents for Rapid PEGylation of Biomolecules

HR Montgomery, MS Messina, EA Doud… - Bioconjugate …, 2022 - ACS Publications
Bioconjugation techniques for biomolecule–polymer conjugation are numerous; however,
slow kinetics and steric challenges generally necessitate excess reagents or long reaction …

Recent advances in biological activities of rhodium complexes: Their applications in drug discovery research

M Sohrabi, M Saeedi, B Larijani, M Mahdavi - European Journal of …, 2021 - Elsevier
Unique structure, characteristic reactivity, and facile synthesis of metal complexes have
made them efficient ligands in drug development research. Among them, rhodium …

Enantiodivergent synthesis of isoindolones catalysed by a Rh (III)-based artificial metalloenzyme

P Mukherjee, A Sairaman, HJ Deka, S Jain… - Nature …, 2024 - nature.com
Combining enzyme and transition-metal catalysis within artificial metalloenzymes has
broadened the scope of new-to-nature reactions and efficiently solved several problems in …

Molecular design, spectroscopic, DFT, pharmacological, and molecular docking studies of novel ruthenium (III)–Schiff base complex: An inhibitor of progression in …

AFH Noureldeen, SW Aziz, SA Shouman… - International journal of …, 2022 - mdpi.com
A novel ruthenium (III)–pyrimidine Schiff base was synthesized and characterized using
different analytical and spectroscopic techniques. Molecular geometries of the ligand and …